Kirin Holdings Company and Fujitsu Limited have jointly conducted a groundbreaking study on food functionality simulation. The study harnessed AI-driven digital tools such as Quantitative Systems Pharmacology (QSP) models and real-world experimental validation to discover a previously unknown mechanism within the gut-brain axis associated with citicoline, a compound known for its cognitive health benefits.
This world-first discovery has resulted from merging advanced QSP technologies developed by Fujitsu and cell-based experimental validation. The process of drug discovery has traditionally been time-consuming and costly, with limitations in substantiating drug efficacy in humans. As a response to these challenges, there has been a rising demand for efficient R&D methodologies. Technologies that combine AI and data science are rapidly gaining traction in response to this need.
By using these disruptive tools, researchers can improve efficacy demonstration in humans without animal testing. These virtual subject generation and in silico simulations greatly increase efficiency in food functionality research. This study is a pioneering global example of large-scale DX (digital transformation) applications in this field.
The discovery of new physiological functions of citicoline, as enabled by the combination of AI-based prediction with experimental validation, is expected to significantly enhance AI-based DX adoption in health science. This could lead to innovative food solutions that foster longevity and well-being in society.
Kirin’s proprietary data was used to build a QSP model that assessed Citicoline’s functionality. Simulations with this model have shown that citicoline intake could enhance cholinergic signalling in the gut – a nerve axis – amplifying acetylcholine levels in the intestines. AI-based analysis also predicted that citicoline could activate neuronal signalling through the gut. This finding was experimentally validated.
This pioneering study opens up possibilities for applications of DX technology in food functionality research. Insights from it may help to elucidate new physiological functions of citicoline, thereby enhancing its value as a functional ingredient for health.
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